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dc.contributor.author
Davel, Lilia E.
dc.contributor.author
Rimmaudo, Laura Elizabeth
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Español, Alejandro Javier
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de la Torre, Eulalia
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Jasnis, María Adela
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Ribeiro, María Laura
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Gotoh, Tomomi
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Sacerdote de Lustig, Eugenia
dc.contributor.author
Sales, María Elena
dc.date.available
2021-01-13T19:19:53Z
dc.date.issued
2004
dc.identifier.citation
Davel, Lilia E.; Rimmaudo, Laura Elizabeth; Español, Alejandro Javier; de la Torre, Eulalia; Jasnis, María Adela; et al.; Different Mechanisms Lead to the Angiogenic Process Induced by Three Adenocarcinoma Cell Lines; Springer; Angiogenesis; 7; 2004; 45–51
dc.identifier.issn
0969-6970
dc.identifier.uri
http://hdl.handle.net/11336/122639
dc.description.abstract
Neoangiogenesis is essential for tumor and metastasis growth, but this complex process does not follow the same activation pathway, at least in tumor cell lines originated from different murine mammary adenocarcinomas. LMM3 cells were the most potent to stimulate new blood vessel formation. This response was significantly reduced by preincubating cells with indomethacin and NS-398, non-selective cyclooxygenase (COX) and COX-2 selective inhibitors, respectively. COX-1 and COX-2 isoenzymes were both highly expressed in LMM3 cells, and we observed that indomethacin was more effective than NS-398 to inhibit prostaglandin E2(PGE2) synthesis. In addition, nitric oxide synthase (NOS) inhibitors, N ωmonomethyl l-arginine and aminoguanidine, also reduced LMM3-induced angiogenesis and nitric oxide (NO) synthesis as well. NOS2 > NOS3 proteins and arginase II isoform were detected in LMM3 cells by Western blot. The latter enzyme was also involved in the LMM3 neovascular response, since the arginase inhibitor, N ω hydroxy l-arginine reduced the angiogenic cascade. On the other hand, parental LM3 cells were able to stimulate neovascularization via COX-1 and arginase products since only indomethacin and N ω hydroxy l-arginine, which diminished PGE2 and urea synthesis, respectively, also reduced angiogenesis. In turn, LM2 cells angiogenic response could be due in fact to PGE2-induced VEGF liberation that stimulated neoangiogenesis at very low levels of NO.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Springer
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
ADENOCARCINOMA
dc.subject
ANGIOGENIC PROCESS
dc.subject
SACERDOTE INVESTIGADORA
dc.subject
PUBLICACIONES
dc.subject.classification
Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Different Mechanisms Lead to the Angiogenic Process Induced by Three Adenocarcinoma Cell Lines
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.identifier.eissn
1573-7209
dc.journal.volume
7
dc.journal.pagination
45–51
dc.journal.pais
Alemania
dc.journal.ciudad
Berlín
dc.description.fil
Fil: Davel, Lilia E.. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Rimmaudo, Laura Elizabeth. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Español, Alejandro Javier. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: de la Torre, Eulalia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Jasnis, María Adela. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Ribeiro, María Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Centro de Estudios Farmacológicos y Botánicos. Universidad de Buenos Aires. Facultad de Medicina. Centro de Estudios Farmacológicos y Botánicos; Argentina
dc.description.fil
Fil: Gotoh, Tomomi. Kumamoto University; Japón
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Sales, María Elena. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.journal.title
Angiogenesis
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1023/B:AGEN.0000037329.45326.a8
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1023/B:AGEN.0000037329.45326.a8
dc.provenance
Otro
dc.format.espacioDeColor
EscalaGris
dc.format.compresion
No especifica
dc.description.nivelDescripcion
Unidad documental simple
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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