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Artículo

Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors

Todaro, Laura BeatrizIcon ; Christiansen, Silvia Beatriz; Varela, MirtaIcon ; Campodónico, Paola BernadetteIcon ; Pallotta Rodriguez, Maria Guadalupe; Lastiri, José; Sacerdote de Lustig, EugeniaIcon ; Bal, Elisa DoraIcon ; Puricelli, Lydia InesIcon
Fecha de publicación: 10/01/2007
Editorial: Springer
Revista: Journal of Neuro-oncology
ISSN: 0167-594X
e-ISSN: 1573-7373
Idioma: Inglés
Volumen: 83
Páginas: 135–144
Subtipo: Artículo científico
Clasificación temática:
Oncología

Resumen

The neural cell adhesion molecule (NCAM) is involved in the intercellular junctions of neurons and glial cells. We investigated its relevance as a biomarker in gliomas which main characteristic is their high invasiveness. We studied by Western blot the pattern of serum NCAM bands in patients with gliomas (n = 34), with brain metastasis of different primary cancers (n = 27) and with benign brain tumors (n = 22)] compared with healthy controls (n = 69). For densitometric analysis NCAM bands ≥130 kDa (HMW) and <130 kDa (LMW) were clustered. We observed that glioma patients presented higher NCAM HMW and lower NCAM LMW levels than control subjects (P < 0.01). A similar pattern was found in patients with brain metastasis or brain benign tumors, suggesting that the pattern of serum NCAM bands would be useful to detect brain tumor pathology. On the other hand, serum NCAM expression was not associated with the main clinicopathological features of gliomas, including overall survival. Interestingly, we found that 9/12 patients with glioma showed a significant decrease in NCAM HMW/LMW ratio between 1–3 months after successful tumor removal. Thus, serum NCAM could be a useful marker for monitoring treatment. NCAM expression was also analyzed at tissular level in 59 glioma sections from paraffined tumors. We observed that NCAM immunostaining was inversely correlated with the histological grade of malignancy, remaining this association in a multivariate analysis. Besides, loss of NCAM staining was significantly associated with bad prognosis in an univariate analysis.
Palabras clave: NCAM , BRAIN TUMORS , SERUM MARKER , TISSULAR MARKER , SACERDOTE INVESTIGADORA , PUBLICACIONES
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/122692
URL: https://link.springer.com/article/10.1007/s11060-006-9312-0
DOI: https://doi.org/10.1007/s11060-006-9312-0
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Recursos continuos (Eugenia Sacerdote)
Recursos continuos (Eugenia Sacerdote)
Citación
Todaro, Laura Beatriz; Christiansen, Silvia Beatriz; Varela, Mirta; Campodónico, Paola Bernadette; Pallotta Rodriguez, Maria Guadalupe; et al.; Alteration of serum and tumoral neural cell adhesion molecule (NCAM) isoforms in patients with brain tumors; Springer; Journal of Neuro-oncology; 83; 10-1-2007; 135–144
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