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dc.contributor.author
Jasnis, Maria Adela
dc.contributor.author
Klein, Slobodanka Mariana
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Monte, Martin
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Davel, Lilia
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Sacerdote de Lustig, Eugenia
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Algranati, Israel David
dc.date.available
2021-01-13T21:44:48Z
dc.date.issued
1994-04-24
dc.identifier.citation
Jasnis, Maria Adela; Klein, Slobodanka Mariana; Monte, Martin; Davel, Lilia; Sacerdote de Lustig, Eugenia; et al.; Polyamines prevent DFMO-mediated inhibition of angiogenesis; Elsevier; Cancer Letters; 79; 1; 24-4-1994; 39-43
dc.identifier.issn
0304-3835
dc.identifier.uri
http://hdl.handle.net/11336/122697
dc.description.abstract
Tumor growth mainly depend on formation of new blood vessels. DFMO (α-difluoromethylornithine), an inhibitor of polyamine biosynthesis, inhibits tumor growth in many animal tumors. Our investigation was to evaluate the requirement of polyamines for induction of angiogenesis by tumor cells and spleen lymphocytes from tumor-bearing mice. In this regard, we have added DFMO to cell cultures. The neovascular response induced either by tumor cells or spleen lymphocytes was completely abrogated. This inhibition could be reversed by the addition of exogenous putrescine. These findings suggest that the effect of DFMO on angiogenesis is, in part, mediated by the inhibition of polyamine biosynthesis.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
TUMOR
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DFMO
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POLYAMINES
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ANGIOGENESIS
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SACERDOTE INVESTIGADORA
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PUBLICACIONES
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Oncología
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Polyamines prevent DFMO-mediated inhibition of angiogenesis
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.journal.volume
79
dc.journal.number
1
dc.journal.pagination
39-43
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Jasnis, Maria Adela. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Klein, Slobodanka Mariana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Monte, Martin. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Davel, Lilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.description.fil
Fil: Algranati, Israel David. Instituto de Investigaciones Bioquímicas "Fundación Campomar"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Cancer Letters
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/0304383594900604
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/0304-3835(94)90060-4
dc.provenance
Otro
dc.format.espacioDeColor
EscalaGris
dc.format.compresion
No especifica
dc.description.nivelDescripcion
Unidad documental simple
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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