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dc.contributor.author
Jasnis, Maria Adela  
dc.contributor.author
Klein, Slobodanka Mariana  
dc.contributor.author
Monte, Martin  
dc.contributor.author
Davel, Lilia  
dc.contributor.author
Sacerdote de Lustig, Eugenia  
dc.contributor.author
Algranati, Israel David  
dc.date.available
2021-01-13T21:44:48Z  
dc.date.issued
1994-04-24  
dc.identifier.citation
Jasnis, Maria Adela; Klein, Slobodanka Mariana; Monte, Martin; Davel, Lilia; Sacerdote de Lustig, Eugenia; et al.; Polyamines prevent DFMO-mediated inhibition of angiogenesis; Elsevier; Cancer Letters; 79; 1; 24-4-1994; 39-43  
dc.identifier.issn
0304-3835  
dc.identifier.uri
http://hdl.handle.net/11336/122697  
dc.description.abstract
Tumor growth mainly depend on formation of new blood vessels. DFMO (α-difluoromethylornithine), an inhibitor of polyamine biosynthesis, inhibits tumor growth in many animal tumors. Our investigation was to evaluate the requirement of polyamines for induction of angiogenesis by tumor cells and spleen lymphocytes from tumor-bearing mice. In this regard, we have added DFMO to cell cultures. The neovascular response induced either by tumor cells or spleen lymphocytes was completely abrogated. This inhibition could be reversed by the addition of exogenous putrescine. These findings suggest that the effect of DFMO on angiogenesis is, in part, mediated by the inhibition of polyamine biosynthesis.  
dc.format
application/pdf  
dc.language.iso
eng  
dc.publisher
Elsevier  
dc.rights
info:eu-repo/semantics/restrictedAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
TUMOR  
dc.subject
DFMO  
dc.subject
POLYAMINES  
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ANGIOGENESIS  
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SACERDOTE INVESTIGADORA  
dc.subject
PUBLICACIONES  
dc.subject.classification
Oncología  
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Medicina Clínica  
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CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Polyamines prevent DFMO-mediated inhibition of angiogenesis  
dc.type
info:eu-repo/semantics/article  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.journal.volume
79  
dc.journal.number
1  
dc.journal.pagination
39-43  
dc.journal.pais
Países Bajos  
dc.journal.ciudad
Ámsterdam  
dc.description.fil
Fil: Jasnis, Maria Adela. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Klein, Slobodanka Mariana. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Monte, Martin. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Davel, Lilia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina  
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.description.fil
Fil: Algranati, Israel David. Instituto de Investigaciones Bioquímicas "Fundación Campomar"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina  
dc.journal.title
Cancer Letters  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/0304383594900604  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/0304-3835(94)90060-4  
dc.provenance
Otro  
dc.format.espacioDeColor
EscalaGris  
dc.format.compresion
No especifica  
dc.description.nivelDescripcion
Unidad documental simple  
dc.type.subtype
Artículo científico  
dc.type
info:ar-repo/semantics/artículo