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dc.contributor.author
Todaro, Laura Beatriz
dc.contributor.author
Puricelli, Lydia Ines
dc.contributor.author
Gioseffi, Hernan
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Pallotta, María Guadalupe
dc.contributor.author
Lastiri, José
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Bal de Kier Joffe, Elisa
dc.contributor.author
Varela, Mirta
dc.contributor.author
Sacerdote de Lustig, Eugenia
dc.date.available
2021-01-13T21:51:43Z
dc.date.issued
2004-03
dc.identifier.citation
Todaro, Laura Beatriz; Puricelli, Lydia Ines; Gioseffi, Hernan; Pallotta, María Guadalupe; Lastiri, José; et al.; Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type; Elsevier; Neurobiology of Disease; 15; 2; 3-2004; 387-393
dc.identifier.issn
0969-9961
dc.identifier.uri
http://hdl.handle.net/11336/122699
dc.description.abstract
Memory impairment is a process associated with alterations in neuronal plasticity, synapses formation, and stabilization. As the neural cell adhesion molecule (NCAM) plays a key role in synaptic bond stabilization, we analyzed the usefulness of soluble NCAM isoforms in the diagnosis of patients with dementia of the Alzheimer type (DAT). NCAM was measured in the sera of 70 control subjects and 43 DAT patients (with different severity of cognitive impairment, GDS), employing Western blot and densitometric quantification. LMW-NCAM bands (100–130 kDa) decreased significantly with age independently of sex. DAT patients presented values of LMW-NCAM and HMW-NCAM significantly higher than healthy controls of similar age (higher than 130 kDa). Only LMW-NCAM was associated with GDS. Our results suggest that NCAM could be involved in the pathogenesis of DAT disorder and that serum NCAM levels could be useful as differential diagnostic markers of the disease.
dc.format
application/pdf
dc.language.iso
eng
dc.publisher
Elsevier
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.subject
SERUM NCAM
dc.subject
SERUM MARKER
dc.subject
DEMENTIA OF THE ALZHEIMER TYPE
dc.subject
SACERDOTE INVESTIGADORA
dc.subject
PUBLICACIONES
dc.subject.classification
Neurología Clínica
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Medicina Clínica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Neural cell adhesion molecule in human serum. Increased levels in dementia of the Alzheimer type
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.journal.volume
15
dc.journal.number
2
dc.journal.pagination
387-393
dc.journal.pais
Países Bajos
dc.journal.ciudad
Ámsterdam
dc.description.fil
Fil: Todaro, Laura Beatriz. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Puricelli, Lydia Ines. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Gioseffi, Hernan. Hospital Italiano; Argentina
dc.description.fil
Fil: Pallotta, María Guadalupe. Hospital Italiano; Argentina
dc.description.fil
Fil: Lastiri, José. Hospital Italiano; Argentina
dc.description.fil
Fil: Bal de Kier Joffe, Elisa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
dc.description.fil
Fil: Varela, Mirta. Hospital Italiano; Argentina
dc.description.fil
Fil: Sacerdote de Lustig, Eugenia. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
dc.journal.title
Neurobiology of Disease
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0969996103002535
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/https://doi.org/10.1016/j.nbd.2003.11.014
dc.provenance
Otro
dc.format.espacioDeColor
EscalaGris
dc.format.compresion
No especifica
dc.description.nivelDescripcion
Unidad documental simple
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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