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Artículo

Muscarinic receptors are involved in LMM3 tumor cells proliferation and angiogenesis

Rimmaudo, Laura ElizabethIcon ; de la Torre, EulaliaIcon ; Sacerdote de Lustig, EugeniaIcon ; Sales, María ElenaIcon
Fecha de publicación: 09/2005
Editorial: Elsevier
Revista: Biochemical and Biophysical Research Communications
ISSN: 0006-291X
Idioma: Inglés
Volumen: 334
Número: 4
Páginas: 1359-1364
Subtipo: Artículo científico
Clasificación temática:
Oncología

Resumen

Angiogenesis is a process of new blood vessel development from pre-existing vasculature and it plays an essential role in tumor growth and metastases. Here, we investigate the expression of muscarinic acetylcholine receptors (mAchR) and their participation in tumor cell proliferation and angiogenesis ability. Saturation binding assays with the tritiated muscarinic antagonist quinuclidinyl benzilate indicate that LMM3 cells derived from a murine mammary adenocarcinoma express a single class of functional mAchR. Competition binding assays with selective muscarinic antagonists indicate a predominance of M3 receptor subtype. The muscarinic agonist carbachol (CARB) stimulates LMM3 cell proliferation in a concentration dependent manner. The maximal effect induced by 10−9 M CARB was totally blunted by atropine and by the selective M3 and M1 antagonists, para-fluoro hexahydro sila-difenidol (pf-HHSiD) and pirenzepine, respectively. In addition, pf-HHSiD completely blocked in vivo CARB-induced neovascular formation and vascular endothelial growth factor-A in LMM3 tumor cells. We can conclude that mAchR expressed in LMM3 mammary tumor cells positively regulate proliferation and angiogenesis required for tumor progression.
Palabras clave: ANGIOGENESIS , mAchR , METASTASIS , LMM3 , SACERDOTE INVESTIGADORA , PUBLICACIONES
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info:eu-repo/semantics/restrictedAccess Excepto donde se diga explícitamente, este item se publica bajo la siguiente descripción: Creative Commons Attribution-NonCommercial-ShareAlike 2.5 Unported (CC BY-NC-SA 2.5)
Identificadores
URI: http://hdl.handle.net/11336/122739
URL: https://www.sciencedirect.com/science/article/abs/pii/S0006291X05014439
DOI: https://doi.org/10.1016/j.bbrc.2005.07.031
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Recursos continuos (Eugenia Sacerdote)
Recursos continuos (Eugenia Sacerdote)
Citación
Rimmaudo, Laura Elizabeth; de la Torre, Eulalia; Sacerdote de Lustig, Eugenia; Sales, María Elena; Muscarinic receptors are involved in LMM3 tumor cells proliferation and angiogenesis; Elsevier; Biochemical and Biophysical Research Communications; 334; 4; 9-2005; 1359-1364
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