Effect of nicotin, cystosin, lobelin, coniin, piperidin and quaternary ammonias on adrenal secretion

Abstract

Nicotin is the type of a group of substances, one of whose characteristic properties is the capacity first to stimulate then to paralyze sympathetic ganglion cells (Langley, 1890, 1896, 1919; Langley and Dickinson, 1889, 1890). The adrenals receive sympathetic innervation by means of the major splanchnics and accessorily through the minor splanchnics. The adrenal medulla has a common embryological origin with the sympathetic ganglia Epinephrin produces sympathico-mimetic effects. All these facts lend a special interest to the study of the influence of nicotin and drugs of similar properties on adrenal secretion.