The hypophysis and secretion of insulin

Abstract

The action of the hypophysis on the pancreas has been demonstrated by a number of direct and indirect proofs. The latter, first reported from this Institute, are as follows: (a) Complete kypophysectomy or anterior (distal) lobe removal produces: (1) Marked sensitivity to the hypoglycemic and toxic action of insulin and other hypoglycemie agents such as phloridzin, fasting, etc. (2) Reduction of intensity of pancreatic and phloridzin diabetes. (3) A rapid fall in blood sugar and tissue glycogen during fasting; of non-pancreatic origin since it occurs after pancreatectomy. The hypoglycemic symptoms can be relieved by prompt administration of glucose, or prevented by a carbohydrate or protein, but not fat diet.