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dc.contributor.author
Houssay, Bernardo Alberto
dc.contributor.author
Martinez, Carlos
dc.date.available
2022-01-20T01:10:57Z
dc.date.issued
1947-05-23
dc.identifier.citation
Houssay, Bernardo Alberto; Martinez, Carlos; Experimental diabetes and diet; American Association for the Advancement of Science; Science; 105; 2734; 23-5-1947; 548-549
dc.identifier.issn
0036-8075
dc.identifier.uri
http://hdl.handle.net/11336/150367
dc.description.abstract
In the experiments described the following observations have been made: (1) The toxic and diabetogenic action of alloxan increases in rats fed a low protein diet and even more so in the case of a high lard or ox fat diet. (2) The action of these fat diets was corrected by the addition of methionine, thiouracil, or coconut oil, but there was no modification either by addition of choline or sulfonamide or by increase in the protein proportion. (3) In rats fed other high fat diets (olive oil, butter) the actions of alloxan were not modified, but there was a slight diminution when high oleomargarine or corn oil diets were fed. However, complete protection was observed when a high coconut oil diet was administered. (4) The unfavorable effect of the high lard diet was observed also on the initiation and evolution of diabetes due to subtotal pancreatectomy. Contrarily, feeding a high protein diet and especially treatment with thiouracil had a favorable effect. (5) Diabetes appeared first in subtotal pancreatectomized rats which were overfed, then in those which ate ad libitum, and finally in those which were underfed. Diabetes appeared in rats fed a single meal before it did in those eating the same amount of food divided into three meals,
dc.format
text/plain
dc.language.iso
eng
dc.publisher
American Association for the Advancement of Science
dc.rights
info:eu-repo/semantics/restrictedAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HOUSSAY, BERNARDO A.
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HOUSSAY EL INVESTIGADOR
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EL INVESTIGADOR
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PUBLICACIONES CIENTIFICAS
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PUBLICACIONES
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CARLOS MARTINEZ
dc.subject
ENDOCRINOLOGIA
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DIABETES MELLITUS
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DIETARY FATS
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ANIMALS
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OIL OLIVE
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OIL COCONUT
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Fisiología
dc.subject.classification
Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
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Filosofía, Historia y Filosofía de la Ciencia y la Tecnología
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Filosofía, Ética y Religión
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HUMANIDADES
dc.title
Experimental diabetes and diet
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.description.version
derivada
dc.journal.volume
105
dc.journal.number
2734
dc.journal.pagination
548-549
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Washington
dc.description.fil
Fil: Houssay, Bernardo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Martinez, Carlos. Fundación de Instituto de Biología y Medicina Experimental; Argentina
dc.journal.title
Science
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://www.science.org/doi/10.1126/science.105.2734.548
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1126/science.105.2734.548.
dc.provenance
Fundación IBYME/IBYME. Biblioteca Bernardo A. Houssay
dc.format.espacioDeColor
BlancoNegro
dc.relation.jurisdiccion
Ciudad de Buenos Aires
dc.format.compresion
Si
dc.description.volumenYsoporte
papel
dc.relation.organismoFinanciador
Fundación de Instituto de Biología y Medicina Experimental
dc.relation.organismoFinanciador
CONICET
dc.relation.organismoFinanciador
Fundacion Williams.
dc.relation.nombreProyecto
Proyecto Houssay y Leloir
dc.relation.productor
IBYME
dc.description.serieArchivo
TIBYME
dc.description.nivelDescripcion
Unidad documental simple
dc.provenance.donante
Fundación IByME
dc.relation.codigoReferencia
AR02675-3ACder0332
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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