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dc.contributor.author
Houssay, Bernardo A.
dc.contributor.author
Anderson, Evelyn
dc.date.available
2022-05-06T00:56:00Z
dc.date.issued
1949-01-12
dc.identifier.citation
Houssay, Bernardo A.; Anderson, Evelyn; Diabetogenic action of purified anterior pituitary hormones; Endocrine Society; Endocrinology; 45; 6; 12-1-1949; 627-629
dc.identifier.issn
0013-7227
dc.identifier.uri
http://hdl.handle.net/11336/156697
dc.description.abstract
This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.
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text/plain
dc.language.iso
eng
dc.publisher
Endocrine Society
dc.relation
http://hdl.handle.net/11336/126924
dc.rights
info:eu-repo/semantics/openAccess
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.subject
HOUSSAY, BERNARDO ALBERTO
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EL INVESTIGADOR
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HOUSSAY EL INVESTIGADOR
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PUBLICACIONES CIENTIFICAS
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PUBLICACIONES
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ENDOCRINOLOGY
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DIABETES
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PITUITARY
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Fisiología
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Medicina Básica
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CIENCIAS MÉDICAS Y DE LA SALUD
dc.title
Diabetogenic action of purified anterior pituitary hormones
dc.type
info:eu-repo/semantics/article
dc.type
info:eu-repo/semantics/publishedVersion
dc.journal.volume
45
dc.journal.number
6
dc.journal.pagination
627-629
dc.journal.pais
Estados Unidos
dc.journal.ciudad
Oxford
dc.description.fil
Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; Argentina
dc.description.fil
Fil: Anderson, Evelyn. National Institutes of Health; Estados Unidos
dc.journal.title
Endocrinology
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/45/6/627/2774616
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/endo-45-6-627
dc.provenance
Fundación IBYME/IBYME. Biblioteca Bernardo A. Houssay
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BlancoNegro
dc.relation.jurisdiccion
Ciudad de Buenos Aires
dc.format.compresion
Si
dc.description.volumenYsoporte
papel
dc.relation.organismoFinanciador
Fundación de Instituto de Biología y Medicina Experimental
dc.relation.organismoFinanciador
Fundacion Williams.
dc.relation.organismoFinanciador
Consejo Nacional de Investigaciones Científicas y Técnicas
dc.relation.nombreProyecto
Proyecto Houssay y Leloir
dc.relation.productor
IBYME
dc.description.serieArchivo
AR02675-AC3der-0335
dc.description.nivelDescripcion
Unidad documental simple
dc.type.subtype
Artículo científico
dc.type
info:ar-repo/semantics/artículo
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