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dc.contributor.author
Houssay, Bernardo A.  
dc.contributor.author
Anderson, Evelyn  
dc.date.available
2022-05-06T00:56:00Z  
dc.date.issued
1949-01-12  
dc.identifier.citation
Houssay, Bernardo A.; Anderson, Evelyn; Diabetogenic action of purified anterior pituitary hormones; Endocrine Society; Endocrinology; 45; 6; 12-1-1949; 627-629  
dc.identifier.issn
0013-7227  
dc.identifier.uri
http://hdl.handle.net/11336/156697  
dc.description.abstract
This communication deals with the diabetogenic action of three of the anterior pituitary hormones, namely growth hormone, adrenocorticotrophic hormone (ACTH) and prolactin. Previous work has indicated that purified growth hormone is diabetogenic (Marx et al., 1943; Houssay, 1945). The growth hormone, which had been prepared by Armour and Co. (lots #8KR32 and #3PKR3) exhibited a purity, as judged by the electrophoretic diagram, of approximately 84 per cent of a single component which had a mobility comparable to that of purified growth hormone. Assay of the material in a 60–70 gram hypophysectomized rat showed that a 50 gamma dose per day caused a body increment of 1.0 gram per day. The ACTH, which was also supplied by the Armour Laboratories (lot #45-A-4), had been prepared by a modification of the Sayers method. Biological assay on hypophysectomized rats, making use of the ascorbic acid depletion method of Sayers et al. (1948), showed a potency of 96 per cent.  
dc.format
text/plain  
dc.language.iso
eng  
dc.publisher
Endocrine Society  
dc.relation
http://hdl.handle.net/11336/126924  
dc.rights
info:eu-repo/semantics/openAccess  
dc.rights.uri
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/  
dc.subject
HOUSSAY, BERNARDO ALBERTO  
dc.subject
EL INVESTIGADOR  
dc.subject
HOUSSAY EL INVESTIGADOR  
dc.subject
PUBLICACIONES CIENTIFICAS  
dc.subject
PUBLICACIONES  
dc.subject
ENDOCRINOLOGY  
dc.subject
DIABETES  
dc.subject
PITUITARY  
dc.subject.classification
Fisiología  
dc.subject.classification
Medicina Básica  
dc.subject.classification
CIENCIAS MÉDICAS Y DE LA SALUD  
dc.title
Diabetogenic action of purified anterior pituitary hormones  
dc.type
info:eu-repo/semantics/article  
dc.type
info:eu-repo/semantics/publishedVersion  
dc.journal.volume
45  
dc.journal.number
6  
dc.journal.pagination
627-629  
dc.journal.pais
Estados Unidos  
dc.journal.ciudad
Oxford  
dc.description.fil
Fil: Houssay, Bernardo A.. Fundación de Instituto de Biología y Medicina Experimental; Argentina  
dc.description.fil
Fil: Anderson, Evelyn. National Institutes of Health; Estados Unidos  
dc.journal.title
Endocrinology  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/url/https://academic.oup.com/endo/article/45/6/627/2774616  
dc.relation.alternativeid
info:eu-repo/semantics/altIdentifier/doi/http://dx.doi.org/10.1210/endo-45-6-627  
dc.provenance
Fundación IBYME/IBYME. Biblioteca Bernardo A. Houssay  
dc.format.espacioDeColor
BlancoNegro  
dc.relation.jurisdiccion
Ciudad de Buenos Aires  
dc.format.compresion
Si  
dc.description.volumenYsoporte
papel  
dc.relation.organismoFinanciador
Fundación de Instituto de Biología y Medicina Experimental  
dc.relation.organismoFinanciador
Fundacion Williams.  
dc.relation.organismoFinanciador
Consejo Nacional de Investigaciones Científicas y Técnicas  
dc.relation.nombreProyecto
Proyecto Houssay y Leloir  
dc.relation.productor
IBYME  
dc.description.serieArchivo
AR02675-AC3der-0335  
dc.description.nivelDescripcion
Unidad documental simple  
dc.type.subtype
Artículo científico  
dc.type
info:ar-repo/semantics/artículo