Diabetogenic action of different preparations of growth hormone

Abstract

The diabetogenic action of the anterior pituitary growth hormone in dogs and cats which had been subjected to subtotal pancreatectomy was observed by Houssay and Anderson (1949 a and b). The dogs received growth hormone in dosages of 50 mg/kg/day and the cats, 25 mg/kg/day. The purpose of that study was to find out the diabetogenic action, if any, of somatotrophin, adrenocorticotrophin and prolactin. The minimal effective doses were not investigated. In the present study, experiments were carried out a) to determine the minimal diabetogenic dose in subtotally depancreatized dogs, and b) to compare the diabetogenic action of three growth hormone preparations.